Journal: Pharmaceutics

Article Title: A Computational Model for the Release of Bioactive Molecules by the Hydrolytic Degradation of a Functionalized Polyester-Based Scaffold

doi: 10.3390/pharmaceutics15030815

Figure Lengend Snippet: Parameters used for the model implemented in COMSOL Multiphysics ® for PLGA.

Article Snippet: The simulation framework is divided into the following steps: (i) firstly, a mathematical model of the hydrolytic degradation for PLLA-based materials was found in the literature, and implemented in the COMSOL Multiphysics ® Finite Element (FE) simulation platform; (ii) the model parameters were calibrated and validated through experimental data of in vitro degradation of PLLA pellets; (iii) the model was implemented on the externally grafted 3D complex scaffold (first scenario), and on the one presenting an internally grafted macroporosity (second scenario), with different delivery conditions (i.e., all and only four central opening channels); (iv) finally, the optimal design was selected by evaluating the degradation of the contact surface and the release of the degradation products, over time and space.

Techniques: Concentration Assay, Diffusion-based Assay